Sanson, Alice and Bosch, Oliver J. (2022) Dysfunctions of brain oxytocin signaling: Implications for poor mothering. NEUROPHARMACOLOGY, 211: 109049. ISSN 0028-3908, 1873-7064
Full text not available from this repository. (Request a copy)Abstract
Good mothering has profound impact on both the mother's and the young's well-being. Consequently, experiencing inadequate maternal care - or even neglect - in the first stages of life is a major risk factor for the development of psychiatric disorders, and even for poor parenting towards the future offspring. Thus, understanding the neurobiological basis of maternal neglect becomes crucial. Along with other neurotransmitters and neuropeptides, oxytocin (OXT) has long been known as one of the main modulators of maternal behavior. In rodents, disruptions of central OXT transmission have been associated with poor maternal responses, like impaired onset of nursing behaviors, and reduced care and defense of the pups. Importantly, such behavioral and molecular deficits can be transmitted through generations, creating a vicious circle of low-quality maternal behavior. Similarly, evidence from human studies shows that OXT signaling is defective in conditions of inadequate mothering and child neglect. On those premises, this review aims at providing a comprehensive overview of animal and human studies linking perturbed OXT transmission to poor maternal behavior. Considering the important fallouts of inadequate maternal responses, we believe that unraveling the alterations in OXT transmission might provide useful insights for a better understanding of maternal neglect and, ultimately, for future intervention approaches.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MEDIAL PREOPTIC AREA; MATERNAL-BEHAVIOR; PLASMA OXYTOCIN; POSTPARTUM DEPRESSION; CHILD-ABUSE; INTERGENERATIONAL TRANSMISSION; INTRANASAL OXYTOCIN; SUPRAOPTIC NUCLEUS; NATURAL VARIATION; Maternal behavior; Maternal neglect; Oxytocin; Oxytocin receptor antagonist; Postpartum depression |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Molecular and Cellular Neurobiology (Prof. Dr. Peter J. Flor) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Nov 2023 10:36 |
| Last Modified: | 07 Nov 2023 10:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56674 |
Actions (login required)
 |
View Item |
