Schueler-Toprak, Susanne and Ortmann, Olaf and Buechler, Christa and Treeck, Oliver (2022) The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis. BIOMEDICINES, 10 (10): 2503. ISSN , 2227-9059
Full text not available from this repository. (Request a copy)Abstract
Polycystic ovary syndrome (PCOS) and endometriosis are frequent diseases of the female reproductive tract causing high morbidity as they can significantly affect fertility and quality of life. Adipokines are pleiotropic signaling molecules secreted by white or brown adipose tissues with a central role in energy metabolism. More recently, their involvement in PCOS and endometriosis has been demonstrated. In this review article, we provide an update on the role of adipokines in both diseases and summarize previous findings. We also address the results of multi-omics approaches in adipokine research to examine the role of single nucleotide polymorphisms (SNPs) in genes coding for adipokines and their receptors, the secretome of adipocytes and to identify epigenetic alterations of adipokine genes that might be conferred from mother to child. Finally, we address novel data on the role of brown adipose tissue (BAT), which seems to have notable effects on PCOS. For this review, original research articles on adipokine actions in PCOS and endometriosis are considered, which are listed in the PubMed database.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BROWN ADIPOSE-TISSUE; CIRCULATING OMENTIN-1 LEVELS; MESSENGER-RNA EXPRESSION; TYPE-2 DIABETES-MELLITUS; VASPIN GENE-EXPRESSION; LEPTIN RECEPTOR LEVELS; INSULIN-RESISTANCE; STROMAL CELLS; IN-VITRO; METABOLIC SYNDROME; polycystic ovary syndrome; endometriosis; adipokine; batokine; white adipose tissue; brown adipose tissue; obesity; infertility; single nucleotide polymorphism; omics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 12 Oct 2023 06:11 |
| Last Modified: | 12 Oct 2023 06:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56720 |
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