Harrer, Dennis C. and Jakob, Marcus and Vogelhuber, Martin and Lueke, Florian and Utpatel, Kirsten and Corbacioglu, Selim and Herr, Wolfgang and Reichle, Albrecht and Heudobler, Daniel (2022) Biomodulatory therapy induces durable remissions in multi-system Langerhans cell histiocytosis. LEUKEMIA & LYMPHOMA, 63 (12). pp. 2858-2868. ISSN 1042-8194, 1029-2403
Full text not available from this repository. (Request a copy)Abstract
Langerhans cell histiocytosis (LCH) is rare hematological neoplasia originating from the aberrant proliferation of CD207-positive dendritic cells. Refractory multi-system LCH is difficult to treat necessitating the continuous development of different salvage therapies. At our medical center, eleven patients (age 11 months to 77 years) with multi-system LCH were treated on a compassionate use basis with metronomic biomodulation therapy (MBT) involving the daily oral application of low-dose trofosfamide, etoricoxib, pioglitazone and low-dose dexamethasone. Overall, four patients including two heavily pretreated pediatric patients achieved ongoing complete remission. Moreover, partial disease remission was observed in three patients, and four patients attained stable disease. MBT demonstrated high activity against multi-system LCH even in patients, refractory to multiple systemic chemotherapies. Further confirmation of efficacy should be systematically evaluated in prospective trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANGIOSTATIC THERAPY; PHASE-II; KAPPA-B; PIOGLITAZONE; TROFOSFAMIDE; ROFECOXIB; DISEASE; VEMURAFENIB; ETORICOXIB; CARCINOMA; Langerhans-cell-histiocytosis; biomodulation; anakoinosis; metronomic chemotherapy; anti-inflammation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V. |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Nov 2023 13:01 |
| Last Modified: | 14 Nov 2023 13:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56730 |
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