Baumgartner, Simon and Lubnow, Matthias and Malfertheiner, Maximilian Valentin and Philipp, Alois and Foltan, Maik and Lunz, Dirk and Mueller, Thomas and Fisser, Christoph (2022) Major Bleeding and Thromboembolic Events in Veno-Venous Extracorporeal Membrane Oxygenation-Patients With Isolated Respiratory Failure. ASAIO JOURNAL, 68 (12). pp. 1529-1535. ISSN 1058-2916, 1538-943X
Full text not available from this repository. (Request a copy)Abstract
Bleeding and thromboembolic events are common during veno-venous extracorporeal membrane oxygenation (vvECMO). It is unknown whether these complications are driven by the ECMO system itself, multiorgan-failure, or both. The aim of this study was to assess the prevalence of bleeding and thromboembolic events in patients with isolated respiratory failure. Patients with vvECMO were retrospectively included from March 2009 to October 2017. Exclusion included any organ failure other than respiratory. Major bleeding was defined as a decrease in hemoglobin >= 2 g/dl per 24 hours, the requirement for transfusion of >= 2 packed red blood cell concentrates per 24 hours, any retroperitoneal, pulmonary, central nervous system bleeding, or bleeding requiring surgery. Thromboembolic events were assessed by duplex sonography or CT scan. Of 601 patients, 123 patients with a mean age of 49 +/- 15 years and a median Sepsis-related Organ Failure Assessment score of 8 (7-9) were eligible for the analysis. Major bleeding was observed in 73%; 35% of all bleedings occurred on the day of or after ECMO initiation. A more pronounced decrease of PaCO2 after ECMO initiation was seen in patients with intracranial bleeding (ICB) compared with those without. Thromboembolic events were noted in 30%. The levels of activated prothrombin time, fibrinogen, platelet count, or D-dimers affected neither bleeding nor the prevalence of thromboembolic events.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | THROMBOSIS; extracorporeal membrane oxygenation; ARDS; ECMO; bleeding; thromboembolic; complication |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Nov 2023 15:08 |
| Last Modified: | 21 Nov 2023 15:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56760 |
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