Schneider, Franziska and Gessner, Andre and El-Najjar, Nahed (2022) Efficacy of Vancomycin and Meropenem in Central Nervous System Infections in Children and Adults: Current Update. ANTIBIOTICS-BASEL, 11 (2): 173. ISSN 2079-6382,
Full text not available from this repository. (Request a copy)Abstract
The current antimicrobial therapy of bacterial infections of the central nervous system (CNS) in adults and pediatric patients is faced with many pitfalls as the drugs have to reach necessary levels in serum and cross the blood-brain barrier. Furthermore, several studies report that different factors such as the structure of the antimicrobial agent, the severity of disease, or the degree of inflammation play a significant role. Despite the available attempts to establish pharmacokinetic (PK) modeling to improve the required dosing regimen for adults and pediatric patients, conclusive recommendations for the best therapeutic strategies are still lacking. For instance, bacterial meningitis, the most common CNS infections, and ventriculitis, a severe complication of meningitis, are still associated with 10% and 30% mortality, respectively. Several studies report on the use of vancomycin and meropenem to manage meningitis and ventriculitis; therefore, this review aims to shed light on the current knowledge about their use in adults and pediatric patients. Consequently, studies published from 2015 until mid-July 2021 are included, and data about the study population, levels of drugs in serum and cerebrospinal fluid (CSF), and measured PK data in serum and CSF are provided. The overall aim is to provide the readers a recent reference that summarizes the pitfalls and success of the current therapy and emphasizes the importance of performing more studies to improve the clinical outcome of the current therapeutical approach.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CEREBROSPINAL-FLUID; POPULATION PHARMACOKINETICS; CONTINUOUS-INFUSION; INTRAVENTRICULAR VANCOMYCIN; CLINICAL-PRACTICE; BRAIN-BARRIER; PENETRATION; MENINGITIS; VENTRICULITIS; ANTIBIOTICS; meningitis; ventriculitis; central nervous infection; meropenem; vancomycin; pharmacokinetics; pharmacodynamics; target attainment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Nov 2023 06:36 |
| Last Modified: | 27 Nov 2023 06:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56797 |
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