Schlosser, Sophie and Tuemen, Deniz and Volz, Barbara and Neumeyer, Katja and Egler, Niklas and Kunst, Claudia and Tews, Hauke Christian and Schmid, Stephan and Kandulski, Arne and Mueller, Martina and Guelow, Karsten (2022) HCC biomarkers - state of the old and outlook to future promising biomarkers and their potential in everyday clinical practice. FRONTIERS IN ONCOLOGY, 12: 1016952. ISSN 2234-943X
Full text not available from this repository. (Request a copy)Abstract
Hepatocellular carcinoma (HCC) is one of the most common and deadly tumors worldwide. Management of HCC depends on reliable biomarkers for screening, diagnosis, and monitoring of the disease, as well as predicting response towards therapy and safety. To date, imaging has been the established standard technique in the diagnosis and follow-up of HCC. However, imaging techniques have their limitations, especially in the early detection of HCC. Therefore, there is an urgent need for reliable, non/minimal invasive biomarkers. To date, alpha-fetoprotein (AFP) is the only serum biomarker used in clinical practice for the management of HCC. However, AFP is of relatively rather low quality in terms of specificity and sensitivity. Liquid biopsies as a source for biomarkers have become the focus of clinical research. Our review highlights alternative biomarkers derived from liquid biopsies, including circulating tumor cells, proteins, circulating nucleic acids, and exosomes, and their potential for clinical application. Using defined combinations of different biomarkers will open new perspectives for diagnosing, treating, and monitoring HCC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CIRCULATING TUMOR-CELLS; LONG NONCODING RNAS; GAMMA-CARBOXY PROTHROMBIN; SERUM ALPHA-FETOPROTEIN; COPY NUMBER ABERRATIONS; CHRONIC LIVER-DISEASE; HEPATOCELLULAR-CARCINOMA; DIAGNOSTIC-VALUE; GLUTAMINE-SYNTHETASE; LIQUID BIOPSY; hepatocellular carcinoma; biomarker; personalized medicine; alpha-fetoprotein; liquid biopsy; circulating tumor cells; circulating nucleic acids; exosomes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 Sep 2023 09:13 |
| Last Modified: | 26 Sep 2023 09:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56825 |
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