Seliger, Corinna and Meyer, Anne-Louise and Leidgens, Verena and Rauer, Lisa and Moeckel, Sylvia and Jachnik, Birgit and Proske, Judith and Dettmer, Katja and Rothhammer-Hampl, Tanja and Kaulen, Leon D. and Riemenschneider, Markus J. and Oefner, Peter J. and Kreutz, Marina and Schmidt, Nils-Ole and Merrill, Marsha and Uhl, Martin and Renner, Kathrin and Vollmann-Zwerenz, Arabel and Proescholdt, Martin and Hau, Peter (2022) Metabolic Heterogeneity of Brain Tumor Cells of Proneural and Mesenchymal Origin. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (19): 11629. ISSN , 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Brain-tumor-initiating cells (BTICs) of proneural and mesenchymal origin contribute to the highly malignant phenotype of glioblastoma (GB) and resistance to current therapies. BTICs of different subtypes were challenged with oxidative phosphorylation (OXPHOS) inhibition with metformin to assess the differential effects of metabolic intervention on key resistance features. Whereas mesenchymal BTICs varied according to their invasiveness, they were in general more glycolytic and less responsive to metformin. Proneural BTICs were less invasive, catabolized glucose more via the pentose phosphate pathway, and responded better to metformin. Targeting glycolysis may be a promising approach to inhibit tumor cells of mesenchymal origin, whereas proneural cells are more responsive to OXPHOS inhibition. Future clinical trials exploring metabolic interventions should account for metabolic heterogeneity of brain tumors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GLIOBLASTOMA CELLS; INITIATING CELLS; CYCLE ARREST; STEM-CELLS; METFORMIN; INHIBITION; EXPRESSION; PROLIFERATION; TEMOZOLOMIDE; PROGRESSION; glioma; metabolism; metformin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Neurologie Medicine > Abteilung für Neuropathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Nov 2023 13:58 |
| Last Modified: | 27 Nov 2023 13:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56839 |
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