Zabka, Matej and Gschwind, Ruth M. (2022) Substrate Photoswitching for Rate Enhancement of a Organocatalytic Cyclization Reaction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2022 (26): e202200048. ISSN 1434-193X, 1099-0690
Full text not available from this repository. (Request a copy)Abstract
In this article, we report that applying in situ LED-NMR irradiation with appropriate wavelength resulted in the photo-switching of an alpha,beta-unsaturated hydrazone C=N double bond configuration. This reaction was previously reported to be the first step in a chiral Bronsted acid-catalyzed cyclization reaction, where the minor but stable Z-isomer is the reactive intermediate. By enhancing the rate of the isomerization, we could show that the overall rate of the cyclization could be increased and followed directly by NMR kinetics. Exclusively light with a specific wavelength matching the isomerization process affected the cyclization. The light- and acid-mediated isomerization provide complementary pathways that can be exploited in synthetic applications to increase reaction rates of asymmetric transformations, especially in reactions requiring high loadings of elaborate chiral catalysts.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NMR-SPECTROSCOPY; ISOMERIZATION; PHOTOISOMERIZATION; ILLUMINATION; SWITCHES; ALKENES; IMINES; STATES; SITU; Hydrazones; NMR spectroscopy; Organocatalysis; Photoswitching; Reaction mechanism |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. Ruth Gschwind |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Dec 2023 09:05 |
| Last Modified: | 05 Dec 2023 09:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56879 |
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