Spoerl, Steffen and Spoerl, Silvia and Reil, Stephanie and Gerken, Michael and Ludwig, Nils and Taxis, Juergen and Fischer, Rene and Ettl, Tobias and Reichert, Torsten E. and Spanier, Gerrit (2022) Prognostic Value of Perineural Invasion on Survival and Recurrence in Oral Squamous Cell Carcinoma. DIAGNOSTICS, 12 (5): 1062. ISSN , 2075-4418
Full text not available from this repository. (Request a copy)Abstract
A diagnosis of perineural invasion (PNI) is widely accepted as an unfavorable prognostic factor in various solid malignancies. Although PNI has been described as a high-risk parameter in oral squamous cell carcinoma (OSCC), its role in the current staging manuals of the American Joint Committee on Cancer (AJCC) is rather subordinate. We analysed the prognostic value of PNI on survival and recurrence in a large, multicenter OSCC cohort and a population-based approach. A total of 493 OSCC patients with primary tumor resection to negative margins and concomitant neck dissection between 2010 and 2017 were enrolled. PNI was evaluated in relation to overall survival (OAS) and recurrence-free survival (RFS) using uni- and multi-variable Cox regression. The median follow-up time was 5.0 years and PNI was diagnosed in 48 patients (9.7%). A pathohistological verification of PNI correlated significantly with a deteriorated OAS in uni- (HR 2.312; 95% CI 2.312-3.493, p = 0.001) and multivariable Cox regression (HR 1.820; 95% CI 1.164-2.847, p = 0.009). Additionally, a diagnosis of PNI correlated with increased cumulative, as well as distant, metastasis 5-year-recurrence rates (p = 0.027 and p = 0.011, respectively). The application of adjuvant radiotherapy (RT) or radiochemotherapy (RCT) in patients with PNI did not alter OAS or RFS in survival analysis when compared to patients without PNI. The results underline the adverse impact of PNI on the survival and recurrence of surgically treated OSCC patients. Based on our findings, we highly recommend an emphasis on PNI in the TNM staging concept.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VASCULAR INVASION; CANCER; METASTASIS; MECHANISMS; oral squamous cell carcinoma; oral cancer; PNI; perineural invasion; survival; recurrence |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V. |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Dec 2023 13:51 |
| Last Modified: | 05 Dec 2023 13:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56927 |
Actions (login required)
 |
View Item |
