Ivanova, I. and Kurz, B. and Lang, K. and Maisch, T. and Berneburg, M. and Kamenisch, Y. (2022) Investigation of the HelioVital filter foil revealed protective effects against UVA1 irradiation-induced DNA damage and against UVA1-induced expression of matrixmetalloproteinases (MMP) MMP1, MMP2, MMP3 and MMP15. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 21 (3). pp. 361-372. ISSN 1474-905X, 1474-9092
Full text not available from this repository. (Request a copy)Abstract
The damaging effects of solar ultraviolet (UV) radiation exposure to human skin are well known and can reach from accelerated skin aging (photoaging) to skin cancer. Much of the damaging effects of solar UVA (320-400 nm) radiation is associated with the induction of reactive oxygen species (ROS), which are capable to cause oxidative damage to DNA like the oxidized guanosine 8-hydroxy-2' -deoxyguanosine (8-OHdG). Therefore, new UV protective strategies, have to be tested for their efficiency to shield against UV induced damage. We investigated the protective effects of HelioVital sun protection filter foil against UVA1 irradiation in skin cells. It could be shown, that HelioVital sun protection filter foil has protective effects against UVA1 irradiation induced changes in matrix metalloproteinase (MMP) expression. Furthermore a UVA1-dependant regulation of MMP15 in human fibroblasts could be shown for the first time in this context. In addition, this study demonstrated the protective effect of the HelioVital filter film against UVA1-induced ROS production and DNA damage. These results could pave the way for clinical studies with HelioVital filter foil shielding against the damaging effects of phototherapy and other forms of irradiation therapy, thereby increasing the safety and treatment opportunities of these forms of therapy. [GRAPHICS] .
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MATRIX METALLOPROTEINASES; ULTRAVIOLET-RADIATION; PHOTODYNAMIC THERAPY; ACTINIC KERATOSES; SKIN; GUIDELINES; HELIOTHERAPY; FIBROBLASTS; GENERATION; PSORIASIS; Ultraviolet (UV) radiation; UVA1; HelioVital filter foil; Reactive oxygen species; MMP |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Jan 2024 10:43 |
| Last Modified: | 29 Jan 2024 12:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56962 |
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