Ritu, and Das, Saikat and Tian, Ya-Ming and Karl, Tobias and Jain, Nidhi and Koenig, Burkhard (2022) Photocatalyzed Dehydrogenation of Aliphatic N-Heterocycles Releasing Dihydrogen. ACS CATALYSIS, 12 (16). pp. 10326-10332. ISSN 2155-5435,
Full text not available from this repository. (Request a copy)Abstract
We report the iridium-nickel dual photocatalytic acceptorless and redox neutral dehydrogenation of aliphatic heterocycles yielding cyclic alkenes without overoxidation at room temperature. Excitation of the iridium photocatalyst initiates the formation of a nickel hydride intermediate that yields alkenes and H-2 via beta-hydride elimination. The reaction proceeds regioselectively and the scope was demonstrated by the synthesis of 12 biologically relevant molecules and drugs. In addition, commercially and easily available N-heterocyclic alkane starting materials were converted into functionalized alkenes of high synthetic and commercial value using the method.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VISIBLE-LIGHT-PHOTOREDOX; ACCEPTORLESS DEHYDROGENATION; CATALYZED DEHYDROGENATION; MERCURY-ELECTRODE; NICKEL; COMPLEXES; OXIDATION; COBALT; DESATURATION; HYDROGENATION; dehydrogenation; visible light; N-heterocycles; dihydrogen; redox neutral; iridium-nickel |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Dec 2023 10:46 |
| Last Modified: | 12 Dec 2023 10:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57016 |
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