Mueller, Eva and Drechsler, Markus and Klein, Regina and Heilmann, J. and Estrine, Boris and Kunz, Werner (2022) Physical-chemical and toxicological properties of osmolyte-based cationic surfactants and spontaneously formed low-toxic catanionic vesicles out of them. JOURNAL OF MOLECULAR LIQUIDS, 361: 119549. ISSN 0167-7322, 1873-3166
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In the context of efficient drug delivery systems, catanionic vesicles offer several advantages, such as spontaneous formation and long-term stability. However, especially the cationic component of such vesicles is often toxic. Thus, the search for less toxic, biocompatible amphiphiles, while maintaining the desirable aggregation properties is crucial. In this work, we present cytotoxicity towards the human cell line Hela as well as biodegradability data of some cationic surfactants based on the natural osmolytes choline and ectoine. The synthesis, aggregation and solubility behaviour as well as the stability in water of these compounds is discussed. In order to induce the spontaneous formation of vesicles, several of these cationic surfactants are combined with choline carboxylates with varying chain length in different mixing ratios and characterised with cryo-TEM. Further, the cytotoxic effect of such novel catanionics is evaluated as a function of the cationic-anionic ratio and compared to that of classical combinations of sodium dodecylsulfate and dodecyltrimethylammonium bromide. (C) 2022 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONTAINING GEMINI SURFACTANTS; IONIC LIQUIDS; HOFMEISTER SERIES; PHASE-BEHAVIOR; DRUG-DELIVERY; CYTOTOXICITY; MICELLES; SIZE; BIODEGRADATION; ENCAPSULATION; Choline surfactants; Ectoine surfactants; Catanionic vesicles; Cytotoxicity; Biodegradability |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > Prof. Dr. Werner Kunz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Dec 2023 15:54 |
| Last Modified: | 12 Dec 2023 15:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57030 |
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