Kozole, Judith and Heydn, Rosmarie and Wirkert, Eva and Kuespert, Sabrina and Aigner, Ludwig and Bruun, Tim-Henrik and Bogdahn, Ulrich and Peters, Sebastian and Johannesen, Siw (2022) Direct Potential Modulation of Neurogenic Differentiation Markers by Granulocyte-Colony Stimulating Factor (G-CSF) in the Rodent Brain. PHARMACEUTICS, 14 (9): 1858. ISSN , 1999-4923
Full text not available from this repository. (Request a copy)Abstract
The hematopoietic granulocyte-colony stimulating growth factor (G-CSF, filgrastim) is an approved drug in hematology and oncology. Filgrastim's potential in neurodegenerative disorders is gaining increasingly more attention, as preclinical and early clinical studies suggest it could be a promising treatment option. G-CSF has had a tremendous record as a safe drug for more than three decades; however, its effects upon the central nervous system (CNS) are still not fully understood. In contrast to conceptual long-term clinical application with lower dosing, our present pilot study intends to give a first insight into the molecular effects of a single subcutaneous (s.c.) high-dose G-CSF application upon different regions of the rodent brain. We analyzed mRNA-and in some instances-protein data of neurogenic and non-neurogenic differentiation markers in different regions of rat brains five days after G-CSF (1.3 mg/kg) or physiological saline. We found a continuous downregulation of several markers in most brain regions. Remarkably, cerebellum and hypothalamus showed an upregulation of different markers. In conclusion, our study reveals minor suppressive or stimulatory effects of a single exceptional high G-CSF dose upon neurogenic and non-neurogenic differentiation markers in relevant brain regions, excluding unregulated responses or unexpected patterns of marker expression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | WAXHOLM SPACE ATLAS; HIPPOCAMPAL NEUROGENESIS; STEM-CELLS; PROTEIN; FAMILY; brain repair; neurodegeneration; neurogenesis; neuronal stem cells; G-CSF; high-dose G-CSF; cellular brain therapy; cerebellum; filgrastim safety |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jan 2024 09:19 |
| Last Modified: | 09 Jan 2024 09:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57098 |
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