Reinartz, Gabriele and Eich, Hans Theodor and Pohl, Fabian (2015) DEGRO practical guidelines for the radiotherapy of non-malignant disorders - Part IV Symptomatic functional disorders. STRAHLENTHERAPIE UND ONKOLOGIE, 191 (4). pp. 295-302. ISSN 0179-7158, 1439-099X
Full text not available from this repository. (Request a copy)Abstract
Purpose To summarize the updated DEGRO consensus S2e guideline recommendations for the treatment of benign symptomatic functional disorders with low-dose radiotherapy. Materials and methods This overview reports on the role of low-dose radiotherapy in the treatment of functional disorders in cases of heterotopic ossification (HO) and Graves orbitopathy (GO). The most relevant aspects of the DEGRO S2e Consensus Guideline "Radiation Therapy of Benign Diseases 2014" regarding diagnostics, treatment decision, dose prescription, as well as performance of radiotherapy and results are summarized. Results For both indications (HO, GO), retrospective and some prospective analyses have shown remarkable effects in terms of symptom relief. Nevertheless, the level of evidence (LoE) and the grade of recommendation (GR) vary: LoE 1-2 and GR A-B (HO), LoE 2 and GR B (GO). Conclusion Low-dose radiotherapy for benign symptomatic functional disorders has proven to be effective, according to different authors, for 25-100 % of the patients studied and therefore it may be a reasonable prophylactic and therapeutic option if noninvasive or invasive methods have been used without persistent success. For HO, a single-fraction dose of 7-8 Gy or fractionated radiation with five fractions of 3.5 Gy is recommended. For GO, single-fraction doses of 0.3-2.0 Gy, and total doses of 2.4-20 Gy/series, applied in one daily fraction are recommended.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TOTAL HIP-REPLACEMENT; GRAVES OPHTHALMOPATHY; HETEROTOPIC OSSIFICATION; SYSTEMIC CORTICOSTEROIDS; ORBITAL RADIOTHERAPY; PROGNOSTIC-FACTORS; RADIATION-THERAPY; BLIND TRIAL; PREVENTION; IRRADIATION; Heterotopic ossification; Graves orbitopathy; Benign functional disease; Low-dose radiotherapy; German S2e guideline |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jul 2019 13:07 |
| Last Modified: | 22 Jul 2019 13:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5716 |
Actions (login required)
 |
View Item |
