Kurtz, Armin (2015) Connexins, renin cell displacement and hypertension. CURRENT OPINION IN PHARMACOLOGY, 21. pp. 1-6. ISSN 1471-4892, 1471-4973
Full text not available from this repository. (Request a copy)Abstract
Vascular gap junctions formed by specific connexins proteins Cx37, 40, 43 and 45 are important for proper vascular function. This review outlines that defects of the connexin 40 protein leads to hypertension because of dysfunction of renin secreting cells of the kidney. Thus defects of Cx40 but not of other vascular connexins blunt the negative feedback control of renin secretion by the blood pressure, and moreover, lead to a shift of renin expression from the juxtaglomerular vessels walls into the periglomerular interstitium. Evidence exists to indicate that those findings which were primarily obtained with mice are also relevant for humans.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VASCULAR GAP-JUNCTIONS; NITRIC-OXIDE SYNTHASE; ATRIAL-FIBRILLATION; AORTIC ENDOTHELIUM; EXPRESSION; PROTEIN; ARTERIOLES; MECHANISMS; CONDUCTION; DEFICIENT; |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jul 2019 13:10 |
| Last Modified: | 22 Jul 2019 13:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5720 |
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