Castrop, Hayo (2015) A role for AT1 receptor-associated proteins in blood pressure regulation. CURRENT OPINION IN PHARMACOLOGY, 21. pp. 43-47. ISSN 1471-4892, 1471-4973
Full text not available from this repository. (Request a copy)Abstract
The renin angiotensin-system is one of the most important humoral regulators of blood pressure. The recently discovered angiotensin receptor-associated proteins serve as local modulators of the renin angiotensin-system. These proteins interact with the AT1 receptor in a tissue-specific manner and regulate the sensitivity of the target cell for angiotensin II. The predominant effect of the AT1 receptor-associated proteins on angiotensin II-induced signaling is the modulation of the surface expression of the AT1 receptor. This review provides an overview of our current knowledge with respect to the relevance of AT1 receptor-associated proteins for blood pressure regulation. Two aspects of blood pressure regulation will be discussed in detail: angiotensin II-dependent volume homoeostasis and vascular resistance.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | II TYPE-1 RECEPTOR; RENIN-ANGIOTENSIN SYSTEM; MUSCLE-CELL-GROWTH; INTERACTING MOLECULE; MEDIATED HYPERTENSION; CARDIAC-HYPERTROPHY; KIDNEY; ATRAP; ACTIVATION; ARAP1; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Wolf Hayo Castrop |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jul 2019 13:23 |
| Last Modified: | 22 Jul 2019 13:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5721 |
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