Ohlsson, Ella and Galler, Kerstin M. and Widbiller, Matthias (2022) A Compilation of Study Models for Dental Pulp Regeneration. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (22): 14361. ISSN 1661-6596, 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Efforts to heal damaged pulp tissue through tissue engineering have produced positive results in pilot trials. However, the differentiation between real regeneration and mere repair is not possible through clinical measures. Therefore, preclinical study models are still of great importance, both to gain insights into treatment outcomes on tissue and cell levels and to develop further concepts for dental pulp regeneration. This review aims at compiling information about different in vitro and in vivo ectopic, semiorthotopic, and orthotopic models. In this context, the differences between monolayer and three-dimensional cell cultures are discussed, a semiorthotopic transplantation model is introduced as an in vivo model for dental pulp regeneration, and finally, different animal models used for in vivo orthotopic investigations are presented.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESENCHYMAL STEM-CELLS; ODONTOBLAST-LIKE CELLS; SIDE POPULATION CELLS; DE-NOVO REGENERATION; IN-VITRO; ODONTOGENIC DIFFERENTIATION; APICAL PAPILLA; ANIMAL-MODEL; TISSUE; CULTURE; regenerative endodontics; study model; dental pulp; regeneration; tissue engineering; cell culture techniques; animal models; translational research |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 01 Sep 2023 08:32 |
| Last Modified: | 29 Feb 2024 14:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57214 |
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