Stasch, Johannes-Peter and Schlossmann, Jens and Hocher, Berthold (2015) Renal effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence. CURRENT OPINION IN PHARMACOLOGY, 21. pp. 95-104. ISSN 1471-4892, 1471-4973
Full text not available from this repository. (Request a copy)Abstract
Direct stimulation of soluble guanylate cyclase (sGC) is emerging as a potential new approach for the treatment of renal disorders. sGC catalyzes the formation of cyclic guanosine monophosphate (cGMP), deficiency of which is implicated in the pathogenesis of chronic kidney disease (CKD). Therefore, new classes of drugs sGC stimulators and activators are being investigated in preclinical models under conditions where nitric oxide is deficient. In preclinical models with different etiologies of CKD, the sGC stimulators BAY 41-2272, BAY 41-8543, BAY 60-4552, riociguat and vericiguat and the sGC activators cinaciguat, ataciguat, BI 703704 and GSK2181236A have shown consistently renoprotective effects. Clinical trials are required to confirm these findings in humans, and to ascertain whether these agents could provide a future alternative to guideline-recommended treatments.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | UNILATERAL URETERAL OBSTRUCTION; CHRONIC KIDNEY-DISEASE; NITRIC-OXIDE PRODUCTION; OXIDATIVE STRESS; HEART-FAILURE; PULMONARY-HYPERTENSION; CARDIOVASCULAR-DISEASE; PROGRESSION; FIBROSIS; RATS; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jul 2019 13:13 |
| Last Modified: | 22 Jul 2019 13:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5722 |
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