Petek, Nejc and Brodnik, Helena and Reiser, Oliver and Stefane, Bogdan (2022) Copper- and Photoredox-Catalyzed Cascade to Trifluoromethylated Divinyl Sulfones. JOURNAL OF ORGANIC CHEMISTRY, 88 (10). pp. 6538-6547. ISSN 0022-3263, 1520-6904
Full text not available from this repository. (Request a copy)Abstract
A Cu(I)-photoredox-catalyzed trifluoromethylchlorosulfonylation reaction of terminal alkynes under visible light conditions was developed, giving rise to trifluoromethyl-substituted vinylsulfonyl chlorides, which can subsequently be coupled to a second alkyne under photocatalytic conditions. The transformation proceeds with high regio-and stereoselectivity and can be applied to aliphatic and aromatic alkynes with various functional groups. Trifluoromethyl-substituted divinyl sulfones prepared by this protocol can be readily used as synthetically valuable intermediates as demonstrated with various postmodification examples.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHLOROTRIFLUOROMETHYLATION; COMPLEXES; CHLORIDES; FLUORINE; ALKYNES; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2024 13:41 |
| Last Modified: | 01 Feb 2024 13:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57252 |
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