Krautbauer, Sabrina and Haberl, Elisabeth M. and Eisinger, Kristina and Pohl, Rebekka and Rein-Fischboeck, Lisa and Rentero, Caries and Alvarez-Guaita, Anna and Enrich, Carlos and Grewal, Thomas and Buechler, Christa and Neumeier, Markus (2017) Annexin A6 regulates adipocyte lipid storage and adiponectin release. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 439 (C). pp. 419-430. ISSN 0303-7207,
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Lipid storage and adipokine secretion are critical features of adipocytes. Annexin A6 (AnxA6) is a lipid binding protein regulating secretory pathways and its role in adiponectin release was examined. The siRNA-mediated AnxA6 knock-down in 3T3-L1 preadipocytes impaired proliferation, and differentiation of AnxA6-depleted cells to mature adipocytes was associated with higher soluble adiponectin and increased triglyceride storage. The latter was partly attributed to reduced lipolysis. Accordingly, AnxA6 overexpression in 3T3-L1 adipocytes lowered cellular triglycerides and adiponectin secretion. Indeed, serum adiponectin was increased in AnxA6 deficient mice. Expression analysis identified AnxA6 protein to be more abundant in intra-abdominal compared to subcutaneous adipose tissues of mice and men. AnxA6 protein levels increased in white adipose tissues of obese mice and here, levels were highest in subcutaneous fat. AnxA6 protein in adipocytes was upregulated by oxidative stress which might trigger AnxA6 induction in adipose tissues and contribute to impaired fat storage and adiponectin release. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADIPOSE-TISSUE DEPOTS; CHOLESTEROL TRANSPORT; ADIPOKINE SECRETION; 3T3-L1 CELLS; VISCERAL FAT; IN-VITRO; OBESITY; INSULIN; MICE; ADIPOGENESIS; Intra-abdominal fat; Obesity; Lipid droplet; Lipolysis; Adipokine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 14 Feb 2019 09:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/573 |
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