Tetens, Jens and Heuer, Claas and Heyer, Iris and Klein, Matthias S. and Gronwald, Wolfram and Junge, Wolfgang and Oefner, Peter J. and Thaller, Georg and Krattenmacher, Nina (2015) Polymorphisms within the APOBR gene are highly associated with milk levels of prognostic ketosis biomarkers in dairy cows. PHYSIOLOGICAL GENOMICS, 47 (4). pp. 129-137. ISSN 1094-8341, 1531-2267
Full text not available from this repository. (Request a copy)Abstract
Essentially all highyielding dairy cows experience a negative energy balance during early lactation leading to increased lipomobilization, which is a normal physiological response. However, a severe energy deficit may lead to high levels of ketone bodies and, subsequently, to subclinical or clinical ketosis. It has previously been reported that the ratio of glycerophosphocholine to phosphocholine in milk is a prognostic biomarker for the risk of ketosis in dairy cattle. It was hypothesized that this ratio reflects the ability to break down blood phosphatidylcholine as a fatty acid resource. In the current study, 248 animals from a previous study were genotyped with Illumina BovineSNP50 Bead-Chip, and genome-wide association studies were carried out for the milk levels of phosphocholine, glycerophosphocholine, and the ratio of both metabolites. It was demonstrated that the latter two traits are heritable with h(2) = 0.43 and h(2) = 0.34, respectively. A major quantitative trait locus was identified on cattle chromosome 25. The APOBR gene, coding for the apolipoprotein B receptor, is located within this region and was analyzed as a candidate gene. The analysis revealed highly significant associations of polymorphisms within the gene with glycerophosphocholine as well as the metabolite ratio. These findings support the hypothesis that differences in the ability to take up blood phosphatidylcholine from low-density lipoproteins play an important role in early lactation metabolic stability of dairy cows and indicate APOBR to contain a causative variant.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUBCLINICAL KETOSIS; ENERGY-BALANCE; EARLY LACTATION; KETONE-BODIES; METABOLISM; RECEPTOR; HEALTH; CATTLE; GLUCONEOGENESIS; EXPRESSION; ketosis; metabolomics; GWAS; glycerophosphocholine; phosphocholine; APOBR |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jul 2019 14:10 |
| Last Modified: | 22 Jul 2019 14:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5731 |
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