Mahl, Lina and Ollig, Johanna and Schweihofer, Verena and Wiegand, Lara and Torkler, Phillipp and Haerteis, Silke and Aung, Thiha (2023) Importance and implications of exosomes in nephrology and urology. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 475 (2). pp. 153-166. ISSN 0031-6768, 1432-2013
Full text not available from this repository. (Request a copy)Abstract
Exosomes are extracellular vesicles that are formed by two invaginations of the plasma membrane and can be released by all eukaryotic cells. Because of their bioactive contents, including nucleic acids and proteins, exosomes can activate a variety of functions in their recipient cells. Due to the plethora of physiological and pathophysiological functions, exosomes have received a lot of attention from researchers over the past few years. However, there is still no consensus regarding isolation and characterization protocols of exosomes and their subtypes. This heterogeneity poses a lot of methodical challenges but also offers new clinical opportunities simultaneously. So far, exosome-based research is still mostly limited to preclinical experiments and early-stage clinical trials since the translation of experimental findings remains difficult. Exosomes could potentially play an important role as future diagnostic and prognostic agents and might also be part of the development of new treatment strategies. Therefore, they have previously been investigated in a variety of nephrological and urological conditions such as acute kidney injury or prostate cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RENAL ISCHEMIA-REPERFUSION; PROSTATE-CANCER; EXTRACELLULAR VESICLES; GENE-EXPRESSION; MESSENGER-RNA; STEM-CELLS; BIOGENESIS; RESISTANCE; AQUAPORIN-1; INHIBITION; Exosomes; Extracellular vesicles; Nephrology; Urology; Uro-oncology |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Feb 2024 05:51 |
| Last Modified: | 21 Feb 2024 05:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57324 |
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