Shulman, Howard M. and Cardona, Diana M. and Greenson, Joel K. and Hingorani, Sangeeta and Horn, Thomas and Huber, Elisabeth and Kreft, Andreas and Longerich, Thomas and Morton, Thomas and Myerson, David and Prieto, Victor G. and Rosenberg, Avi and Treister, Nathaniel and Washington, Kay and Ziemer, Mirjana and Pavletic, Steven Z. and Lee, Stephanie J. and Flowers, Mary E. D. and Schultz, Kirk R. and Jagasia, Madan and Martin, Paul J. and Vogelsang, Georgia B. and Kleiner, David E. (2015) NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 21 (4). pp. 589-603. ISSN 1083-8791, 1523-6536
Full text not available from this repository. (Request a copy)Abstract
The 2005 National Institute of Health (NIH) Consensus Conference outlined histopathological diagnostic criteria for the major organ systems affected by both acute and chronic graft-versus-host disease (GVHD). The 2014 Consensus Conference led to this updated document with new information from histopathological studies of GVHD in the gut, liver, skin, and oral mucosa and an expanded discussion of GVHD in the lungs and kidneys. The recommendations for final histological diagnostic categories have been simplified from 4 categories to 3: no GVHD, possible GVHD, and likely GVHD, based on better reproducibility achieved by combining the previous categories of "consistent with GVHD" and "definite GVHD" into the single category of "likely GVHD." Issues remain in the histopathological characterization of GVHD, particularly with respect to the threshold of histological changes required for diagnostic certainty. Guidance is provided for the incorporation of biopsy information into prospective clinical studies of GVHD, particularly with respect to biomarker validation. Published by Elsevier Inc. on behalf of American Society for Blood and Marrow Transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; DONOR LYMPHOCYTE INFUSION; BRONCHIOLITIS OBLITERANS SYNDROME; FIBROSING CHOLESTATIC HEPATITIS; MOFETIL-RELATED COLITIS; MINOR SALIVARY-GLANDS; MYCOPHENOLATE-MOFETIL; NEPHROTIC SYNDROME; HISTOLOGIC FEATURES; Chronic graft-versus-host disease; Allogeneic hematopoietic cell transplantation; Consensus; Diagnosis; Pathology; Histology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jul 2019 14:18 |
| Last Modified: | 22 Jul 2019 14:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5734 |
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