Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures

Gore, Sangram and Baskaran, Sundarababu and Koenig, Burkhard (2022) Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 18. pp. 331-336. ISSN 1860-5397

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Abstract

A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from beta,gamma-unsaturated ketoesters in low melting L-(+)-tartaric acid-N,N-dimethylurea mixtures is reported. This solvent-free method is very general and provides easy access to 5-unsubstituted dihydropyrimidinone-4-carboxylate derivatives in good yields.

Item Type: Article
Uncontrolled Keywords: CALCIUM-CHANNEL BLOCKERS; UREA-SALT MIXTURES; ACID-ESTERS; CYCLOCONDENSATION REACTION; POTENT MIMICS; SOLVENTS; ANTAGONISTS; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; DERIVATIVES; INHIBITOR; green protocol; mild conditions; no additional catalyst; solvent free; triple role of melt
Subjects: 500 Science > 540 Chemistry & allied sciences
Divisions: Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Depositing User: Dr. Gernot Deinzer
Date Deposited: 08 Feb 2024 07:41
Last Modified: 08 Feb 2024 07:41
URI: https://pred.uni-regensburg.de/id/eprint/57393

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