Rupprecht, Rainer and Wetzel, Christian H. and Dorostkar, Mario and Herms, Jochen and Albert, Nathalie L. and Schwarzbach, Jens and Schumacher, Michael and Neumann, Inga D. (2022) Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders? MOLECULAR PSYCHIATRY, 27 (7). pp. 2918-2926. ISSN 1359-4184, 1476-5578
Full text not available from this repository. (Request a copy)Abstract
Efficient treatment of stress-related disorders, such as depression, is still a major challenge. The onset of antidepressant drug action is generally quite slow, while the anxiolytic action of benzodiazepines is considerably faster. However, their long-term use is impaired by tolerance development, abuse liability and cognitive impairment. Benzodiazepines act as positive allosteric modulators of gamma-aminobutyric acid type A (GABA(A)) receptors. 3 alpha-reduced neurosteroids such as allopregnanolone also are positive allosteric GABA(A) receptor modulators, however, through a site different from that targeted by benzodiazepines. Recently, the administration of neurosteroids such as brexanolone or zuranolone has been shown to rapidly ameliorate symptoms in post-partum depression or major depressive disorder. An attractive alternative to the administration of exogenous neurosteroids is promoting endogenous neurosteroidogenesis via the translocator protein 18k Da (TSPO). TSPO is a transmembrane protein located primarily in mitochondria, which mediates numerous biological functions, e.g., steroidogenesis and mitochondrial bioenergetics. TSPO ligands have been used in positron emission tomography (PET) studies as putative markers of microglia activation and neuroinflammation in stress-related disorders. Moreover, TSPO ligands have been shown to modulate neuroplasticity and to elicit antidepressant and anxiolytic therapeutic effects in animals and humans. As such, TSPO may open new avenues for understanding the pathophysiology of stress-related disorders and for the development of novel treatment options.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 18 KDA TSPO; ADULT SEPARATION ANXIETY; TERM BENZODIAZEPINE USE; RECEPTOR MESSENGER-RNA; NEUROACTIVE STEROIDS; MAJOR DEPRESSION; MOUSE MODEL; MITOCHONDRIAL; LIGAND; EXPRESSION; |
| Subjects: | 500 Science > 590 Zoological sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Feb 2024 07:43 |
| Last Modified: | 20 Feb 2024 07:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57487 |
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