Erber, Ramona and Spoerl, Steffen and Mamilos, Andreas and Krupar, Rosemarie and Hartmann, Arndt and Ruebner, Matthias and Taxis, Juergen and Wittenberg, Mareike and Reichert, Torsten E. and Spanier, Gerrit and Spoerl, Silvia (2022) Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (1): 87. ISSN , 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Oral cancer often presents with aggressive behavior and a high risk of recurrence and metastasis. For oral squamous cell carcinoma (OSCC), which is the most frequent histological subtype, therapy strategies include surgery, radiation therapy, chemotherapy, immune checkpoint inhibitors, and EGFR inhibitors. Recently, a Trop-2 antibody-drug conjugate (ADC) has been approved in the United States of America for the treatment of advanced triple-negative breast cancer. However, this ADC has also been tested in other solid tumors including head & neck squamous cell carcinoma. The prognostic impact of Trop-2 has already been reported for several cancers. We studied the prognostic influence of Trop-2 protein expression on OSCC patients' survival. The cohort comprised n = 229 OSCC patients with available archived tumor tissue and corresponding non-neoplastic oral mucosa tissue. Using immunohistochemistry, we investigated Trop-2 expression in both the central and peripheral regions of each tumor and in corresponding non-neoplastic oral mucosa. In patients suffering from OSCC with combined high central and low peripheral Trop-2 expression, five-year overall survival (OS) was 41.2%, whereas 55.6% of OSCC patients who presented lower central and/or higher peripheral tumoral Trop-2 expression were alive after five years (p = 0.075). In multivariate Cox regression, the expression pattern of high central tumoral and lower peripheral Trop-2 expression was significantly correlated with impaired OS (HR = 1.802, 95%-CI: 1.134-2.864; p = 0.013) and recurrence-free survival (RFS) (HR = 1.633, 95%-CI: 1.042-2.560; p = 0.033), respectively, when adjusting for co-variables. Hence, Trop-2 may serve as an independent prognostic biomarker in OSCC. In subsequent studies, the pathophysiological meaning of downregulated Trop-2 expression in the OSCC periphery has to be analyzed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SACITUZUMAB GOVITECAN; CHEMOTHERAPY; CONJUGATE; Trop-2; TACSTD2; tumor associated calcium signal transducer 2; oral squamous cell carcinoma; prognosis; antibody-drug conjugates; immunohistochemistry; biomarker; head and neck cancer |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Feb 2024 08:00 |
| Last Modified: | 20 Feb 2024 08:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57506 |
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