de Vos, Luka and Guel, Tugce and Niebel, Dennis and Bald, Sandra and ter Steege, Adrian and Bieber, Thomas and Wenzel, Joerg (2022) Characterization of B cells in lupus erythematosus skin biopsies in the context of different immune cell infiltration patterns. FRONTIERS IN MEDICINE, 9: 1037408. ISSN , 2296-858X
Full text not available from this repository. (Request a copy)Abstract
Cutaneous lesions in lupus erythematosus (LE) subtypes are heterogenous. In line with the heterogeneity of the clinical presentation, the underlying lesional inflammation in LE skin samples is defined by different immune cell infiltrates. Pathophysiologically, lesional inflammation is driven by autoreactive cytotoxic T cells, targeting keratinocytes; plasmacytoid dendritic cells (pDCs), producing large amounts of interferon (IFN); and B cells, whose function in cutaneous LE is still unclear. This study aims to (a) classify inflammatory patterns with regard to the dominating cell type or cytokine expression and (b) investigating the specific role of B cells in LE skin lesions. Therefore, the immunohistological expression of inflammatory surrogates (CD20, CD123, MXA) in skin samples of n = 119 LE (subtypes: subacute cutaneous LE, chronic discoid LE, chilblain LE, LE tumidus, other LE) and n = 17 patients with inflammatory skin diseases (atopic dermatitis, psoriasis) were assessed. Samples were classified with regard to inflammatory groups. In addition multiplex-immunohistochemical analyses of n = 17 LE skin samples focusing on lesional B cells were conducted. In this study, we show that cutaneous lesions present with eight different inflammatory groups dominated by B cells, pDCs, a strong IFN expression, or overlapping patterns. Altogether, LE subtypes show heterogenous infiltration regardless of LE subtype, certain subtypes display a preference for infiltration groups. Furthermore, lesional B cells either form diffuse infiltrates or pseudofollicular structures, wherein they show antigen-presenting and T cell-activating properties. Altogether, in the light of emerging targeted therapeutic options, we suggest histological assessment in regard to B-cell or pDC preponderance to allow tailored treatment decisions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BELIMUMAB; PATHOGENESIS; INFLAMMATION; inflammation; BLyS; BAFF receptor (BAFF-R); MXA; pDC; interferon; B cell; cutaneous lupus erythematosus |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Feb 2024 09:35 |
| Last Modified: | 20 Feb 2024 09:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57508 |
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