Kanuri, Giridhar and Wagnerberger, Sabine and Landmann, Marianne and Prigl, Eva and Hellerbrand, Claus and Bischoff, Stephan C. and Bergheim, Ina (2015) Effect of acute beer ingestion on the liver: studies in female mice. EUROPEAN JOURNAL OF NUTRITION, 54 (3). pp. 465-474. ISSN 1436-6207, 1436-6215
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The aim of the present study was to assess whether the effects of acute consumption of stout or pilsner beer on the liver differ from those of plain ethanol in a mouse model. Seven-week-old female C57BL/6J mice received either ethanol, stout or pilsner beer (ethanol content: 6 g/kg body weight) or isocaloric maltodextrin solution. Plasma alanine transaminase, markers of steatosis, lipogenesis, activation of the toll-like receptor-4 signaling cascade as well as lipid peroxidation and fibrogenesis in the liver were measured 12 h after acute ethanol or beer intake. Acute alcohol ingestion caused a marked similar to 11-fold increase in hepatic triglyceride accumulation in comparison to controls, whereas in mice exposed to stout and pilsner beer, hepatic triglyceride levels were increased only by similar to 6.5- and similar to 4-fold, respectively. mRNA expression of sterol regulatory element-binding protein 1c and fatty acid synthase in the liver did not differ between alcohol and beer groups. In contrast, expression of myeloid differentiation primary response gene 88, inducible nitric oxide synthases, but also the concentrations of 4-hydroxynonenal protein adducts, nuclear factor kappa B and plasminogen activator inhibitor-1 were induced in livers of ethanol treated mice but not in those exposed to the two beers. Taken together, our results suggest that acute ingestion of beer and herein especially of pilsner beer is less harmful to the liver than the ingestion of plain ethanol.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INDUCED HEPATIC STEATOSIS; INDUCED FATTY LIVER; RAT KUPFFER CELLS; ALCOHOL-FREE BEER; ETHANOL EXPOSURE; FEEDING MODEL; INJURY; ENDOTOXIN; DISEASE; PERMEABILITY; Alcohol; Beer; Female sex; iNOS; Liver |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jul 2019 13:35 |
| Last Modified: | 22 Jul 2019 13:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5752 |
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