Tews, Hauke C. and Kandulski, A. and Schmid, S. and Peschel, G. and Guelow, K. and Schlosser, S. and Schirner, S. and Stroszczynski, C. and Mueller, M. and Jung, E. M. (2022) Contrast enhanced ultrasonography (CEUS) a novel tool to detect intestinal epithelial barrier dysfunction in severe COVID-19 disease. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 81 (2). pp. 177-190. ISSN 1386-0291, 1875-8622
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Ten patients with confirmed COVID-19 disease were studied. Nine patients required intensive care treatment, among them four needed extracorporeal membrane oxygenation (ECMO). Contrast enhanced ultrasonography (CEUS) was performed by one experienced investigator as a bolus injection of up to 2.4 ml of sulphur hexafluoride microbubbles via a central venous catheter. B-Mode evaluation and strain elastography showed mural edema of the small bowel with a thickness of up to 10 mm in all patients. We applied color coded Doppler sonography (CCDS) and power mode with flow-adapted parameters and early, dynamic capillary arterial contrast enhancement of bowel wall structures <10 s to assess perfusion of the small bowel. In all patients, reactive hyperemia was seen in the entire small bowel. In a subgroup of seven patients microbubbles translocated into the intestinal lumen. Thus, high-grade intestinal barrier disruption secondary to SARSCoV-2 infection can be postulated in these patients. This is the first description of perfusion changes and a disruption of the small bowel epithelial barrier in COVID-19 Patients using contrast ultrasonography and elastography.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ULTRASOUND CEUS; EFSUMB GUIDELINES; RECOMMENDATIONS; INJURY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Feb 2024 10:29 |
| Last Modified: | 20 Feb 2024 10:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57591 |
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