Cucuruz, B. and Kopp, R. and Hampe-Hecht, H. and Andercou, O. and Schierling, W. and Pfister, K. and Koller, M. and Noppeney, T. (2022) Treatment of end-stage peripheral artery disease by neuromodulation. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 81 (4). pp. 315-324. ISSN 1386-0291, 1875-8622
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND: Neuromodulation is a therapeutic option to improve limb salvage in end-stage peripheral arterial disease (PAD), but there is no consensus on its indication for spinal cord stimulation (SCS) in PAD patients. OBJECTIVE: The aim of this study was to present the outcome of end-stage PAD patients treated with SCS. METHODS: This study is a retrospective analysis based on a local prospective registry. Neuromodulation was performed if there was: 1) no revascularisation option, and 2) no septicemia, 3) Rutherford stage 4-6. The primary endpoint of the study was limb salvage. Secondary endpoints were reduction in pain or simply pain reduction (assessed using a visual anlog scale/VAS) and improvement in walking distance. RESULTS: Limb salvage was reached in 30/34 patients (88%). Patients reported a significant reduction in pain on the 10-point VAS scale from baseline (median = 7.5, IQR = 7-8) to follow-up at 2 years (median = 0, IQR 0-2.75), p < 0.001. Walking distance also improved from preoperative (median = 50 m, IQR = 20-50 m) to follow-up at 2 years (median = 150 m, IQR 50-272 m), p < 0.001. CONCLUSIONS: SCS implantation in patients with end-stage PAD can enable limb salvage in a high percentage of cases and increase mobility due to pain reduction. The role of microcirculation in these improvements needs to be investigated in further studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SPINAL-CORD STIMULATION; LIMB ISCHEMIA; MORTALITY; Neuromodulation; spinal cord stimulation; end-stage peripheral artery disease; chronic critical limb ischemia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Gefäßchirurgie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Feb 2024 13:33 |
| Last Modified: | 20 Feb 2024 13:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57616 |
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