Werner, Philipp and Burger, Martin and Frank, Florian and Garcke, Harald (2022) A Diffuse Interface Model for Cell Blebbing Including Membrane-Cortex Coupling with Linker Dynamics. SIAM JOURNAL ON APPLIED MATHEMATICS, 82 (3). pp. 1091-1112. ISSN 0036-1399, 1095-712X
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The aim of this paper is to develop suitable models for the phenomenon of cell blebbing, which allow for computational predictions of mechanical effects, including the crucial interaction of the cell membrane and the actin cortex. For this sake we resort to a two phase field model that uses diffuse descriptions of both the membrane and the cortex, which in particular allows for a suitable description of the interaction via linker protein densities. Besides the detailed modeling we discuss some energetic aspects of the models and present a numerical scheme, which allows us to carry out several computational studies. In those we demonstrate that several effects found in experiments can be reproduced, in particular bleb formation by cortex rupture, which was not possible by previous models without the linker dynamics.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SURFACTANTS; MITOSIS; ENERGY; SHAPE; FLOW; cell blebbing; phase field model; interacting interfaces; fluid-structure interaction |
| Subjects: | 500 Science > 510 Mathematics |
| Divisions: | Mathematics > Prof. Dr. Harald Garcke |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2024 12:44 |
| Last Modified: | 15 Feb 2024 12:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57639 |
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