Arzt, Michael and Oldenburg, Olaf and Graml, Andrea and Schnepf, Jurgen and Erdmann, Erland and Teschler, Helmut and Schoebel, Christoph and Woehrle, Holger (2022) Prevalence and predictors of sleep-disordered breathing in chronic heart failure: the SchlaHF-XT registry. ESC HEART FAILURE, 9 (6). pp. 4100-4111. ISSN 2055-5822,
Full text not available from this repository. (Request a copy)Abstract
Aims Heart failure with preserved ejection fraction (HFpEF) is a condition with increasing prevalence. Sleep-disordered breathing (SDB) is an important co-morbidity in HFpEF. The SchlaHF-XT registry evaluated the sex-specific prevalence and predictors of SOB, including obstructive (OSA) and central sleep apnoea, in patients with HFpEF compared with heart failure with mildly reduced (HFmrEF) or reduced (HFrEF) ejection fraction. Methods and results Consecutive adults with chronic heart failure treated according to current guidelines were enrolled. The presence of moderate-to-severe SDB (apnoea-hypopnoea index >= 15/h) was determined using Type 3 polygraphic devices. Of 3289 patients included, 2032 had HFpEF, 559 had HFmrEF, and 698 had HFrEF, of whom 34, 21, 23, and 42%, respectively, were female. Prevalence of SDB in HFpEF was high, but significantly lower than in HFmrEF or HFrEF (36% vs. 41 and 48%, respectively). Rates of SDB in males and females were 41 and 28% in HFpEF, 44 and 30% in HFmrEF, and 50 and 40% in HFrEF. The proportion of males and females with SDB who had OSA was significantly greater in those with HFpEF vs. HFrEF. Male sex, older age, higher body mass index, and New York Heart Association functional Class III/IV were significant predictors of moderate-to-severe SDB in HFpEF patients. Conclusions Prevalence of SDB in HFpEF was high, but lower than in patients with HFmrEF or HFrEF. Moderate-to-severe SDB occurred more frequently in males than in females across the whole spectrum of heart failure. In both sexes, the proportion of OSA in SDB patients with HFpEF was higher than in those with HFrEF.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADAPTIVE SERVO-VENTILATION; EUROPEAN-SOCIETY; APNEA; DIAGNOSIS; CLASSIFICATION; ASSOCIATION; GUIDELINES; PROGNOSIS; IMPACT; ESC; Heart failure with preserved ejection fraction; Heart failure; Obstructive sleep apnoea; Central sleep apnoea; Prevalence; Predictors |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Feb 2024 14:53 |
| Last Modified: | 20 Feb 2024 14:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57693 |
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