Polanetzki, Vanessa and Froeb, Franziska and Baroti, Tina and Schimmel, Margit and Tamm, Ernst R. and Wegner, Michael (2022) Role of the Pbrm1 subunit and the PBAF complex in Schwann cell development. SCIENTIFIC REPORTS, 12 (1): 2651. ISSN 2045-2322
Full text not available from this repository. (Request a copy)Abstract
Myelin sheath formation in the peripheral nervous system and the ensuing saltatory conduction rely on differentiated Schwann cells. We have previously shown that transition of Schwann cells from an immature into a differentiated state requires Brg1 that serves as the central energy generating subunit in two related SWI/SNF-type chromatin remodelers, the BAF and the PBAF complex. Here we used conditional deletion of Pbrm1 to selectively interfere with the PBAF complex in Schwann cells. Despite efficient loss of Pbrm1 early during lineage progression, we failed to detect any substantial alterations in the number, proliferation or survival of immature Schwann cells as well as in their rate and timing of terminal differentiation. As a consequence, postnatal myelin formation in peripheral nerves appeared normal. There were no inflammatory alterations in the nerve or other signs of a peripheral neuropathy. We conclude from our study that Pbrm1 and very likely the PBAF complex are dispensable for proper Schwann cell development and that Schwann cell defects previously observed upon Brg1 deletion are mostly attributable to altered or absent function of the BAF complex.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHROMATIN; IDENTIFICATION; BAF180; GENE |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2024 13:36 |
| Last Modified: | 15 Feb 2024 13:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57695 |
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