Mach, Pawel and Koeninger, Angela and Reisch, Beatrix and Kimmig, Rainer and Gellhaus, Alexandra (2022) Soluble PD-L1 and B7-H4 serum levels during the course of physiological pregnancy. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 87 (3): e13519. ISSN 1046-7408, 1600-0897
Full text not available from this repository. (Request a copy)Abstract
Problem The aim of this study was to evaluate the soluble programmed death-ligand (sPD-L1) and soluble B7-H4 (sB7-H4) serum concentration levels longitudinal throughout the three trimesters of uncomplicated pregnancies. Method of the study sPD-L1 and sB7-H4 levels were determined with enzyme-linked immunosorbent assay (ELISA). The patients (n = 26) were divided into three groups according to the pregnancy trimester. Among 26 women involved in the study 14 had longitudinal sB7-H4 and sPD-L1 measurements in each trimester of pregnancy. Results During the course of pregnancy, the sB7-H4 blood serum levels were significant higher in second trimester than in first and third trimester, whereas sPD-L1 levels increased significantly over the course of pregnancy. Conclusion The highest serum levels of sPD-L1 in the third trimester suggest increasing suppression of maternal immunity throughout pregnancy, whereas elevated sB7-H4 concentration levels in second trimester suggests different profile of T-cell regulation in physiological pregnancy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; REJECTION; EXPRESSION; CD80; IMPLANTATION; MACROPHAGES; INHIBITION; MOLECULES; DECIDUA; WOMEN; B7-H4; PD-L1; pregnancy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Feb 2024 15:27 |
| Last Modified: | 20 Feb 2024 15:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57703 |
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