Blatt, Sebastian and Krueger, Maximilian and Rump, Constantin and Zimmer, Stefanie and Sagheb, Keyvan and Kuenzel, Julian (2022) Differences in PD-L1 Expression between oral and oropharyngeal squamous cell carcinoma. PLOS ONE, 17 (5): e0269136. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Treatment of metastasized or recurrent oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma remains challenging. Targeted antibody-based therapy inter alia for PD-1 / PD-L1 axis shows promising results, but whether PD-L1 expression varies between the subentities remains unclear. The expression pattern of PD-L1 (EPR19759 antibody, Abcam, Berlin, Germany) and p16 (CINtech (R) Histology Kit, Ventana, Oro Valley, USA) was determined immunohistochemically and analyzed by HALO (TM) Image Analysis Software (Indica Lab, Albuquerque, USA). For PD-L1, combined positivity score (CPS), tumor proportion score (TPS) and histoscore, were assessed and results correlated with epidemiological data. In total, 161 patients (OSCC: n = 78, OPSCC: n = 83) were included. A mean of 43.6% (+/- 34.0%) of the specimen showed increased PD-L1 expression that did not differ quantitatively between subentities (TPS: p = 0.159, CPS: p = 0.078), but qualitatively (histoscore: p = 0.003). In the mean follow-up period (45.6 months), contrary to age (p = 0.006) and advanced T-Status (p = 0.018), PD-L1 expression did not correlate with overall (OS, p = 0.191) and recurrence free survival (RFS: p = 0.193) in both subentities. No correlation of p16 and PD-L1 expression was found (p = 0.844). PD-L1 is differentially expressed between OSCC and OPSCC, however without influence on OS. Furthermore, p16 status was not related to PD-L1 expression. This may have implications for future (immune) therapeutical approaches for oral cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN PAPILLOMA-VIRUS; HPV-ASSOCIATED HEAD; PROGNOSTIC BIOMARKER; NECK-CANCER; OPEN-LABEL; CHEMOTHERAPY; IMPACT; PEMBROLIZUMAB; ASSOCIATION; MULTICENTER; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Feb 2024 15:46 |
| Last Modified: | 20 Feb 2024 15:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57732 |
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