Carboni, Lucia and El Khoury, Aram and Beiderbeck, Daniela and Neumann, Inga D. and Mathe, Aleksander A. (2022) Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 57. pp. 1-14. ISSN 0924-977X, 1873-7862
Full text not available from this repository. (Request a copy)Abstract
Anxiety disorders are pervasive psychiatric disorders causing great suffering. The high (HAB) and low (LAB) anxiety-related behaviour rats were selectively bred to investigate neurobiological correlates of anxiety. We compared the level of neuropeptides relevant for anxiety- and depression-related behaviours in selected brain regions of HAB and LAB rats. Increased anxiety and depression-like behaviours of male and female HAB rats in the elevated plus-maze and forced swim tests were accompanied by elevated levels of neuropeptide Y (NPY) in the prefrontal (PFC), frontal (FC) and cingulate cortex (CCx), the striatum, and periaqueductal grey (PAG). Moreover, HAB rats displayed sex-dependent, elevated levels of calcitonin gene-related peptide (CGRP) in PFC, FC, CCx, hippocampus, and PAG. Higher neurokinin A (NKA) levels were detected in CCx, striatum, and PAG in HAB males and in CCx and hypothalamus in HAB females. Increased neurotensin was detected in CCx and PAG in HAB males and in hypothalamus in HAB females. Elevated corticotropin-releasing hormone (CRH) levels appeared in female HAB hypothalamus. Significant correlations were found between anxiety-like behaviour and NPY, CGRP, NKA, and neurotensin, particularly with NPY in CCx and striatum, CGRP in FC and hippocampus, and NKA in entorhinal cortex.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORTICOTROPIN-RELEASING HORMONE; FLINDERS SENSITIVE LINE; MESSENGER-RNA EXPRESSION; FORCED SWIM TEST; CEREBROSPINAL-FLUID; MATERNAL SEPARATION; SEX-DIFFERENCES; ANIMAL-MODEL; DEPRESSION; RECEPTOR; NPY; CGRP; Neurokinin A; Neurotensin; Corticotropin releasing hormone; HAB LAB rats |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jan 2024 11:30 |
| Last Modified: | 26 Jan 2024 11:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57786 |
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