Beutner, Andrea and Kochmann, Sven and Mark, Jonas Josef Peter and Matysik, Frank-Michael (2015) Two-Dimensional Separation of Ionic Species by Hyphenation of Capillary Ion Chromatography x Capillary Electrophoresis-Mass Spectrometry. ANALYTICAL CHEMISTRY, 87 (6). pp. 3134-3138. ISSN 0003-2700, 1520-6882
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The separation of complex mixtures such as biological or environmental samples requires high peak Capacities, which cannot be established with a single separation technique. Therefore, multidimensional Systems are in demand. In this work, we present the hyphenation of the to most important (orthogonal) techniques in ion analysis, namely, ion Chromatography (IC) and Capillary electrophoresis (CE), in combination with mass spectrometry. A modulator was developed ensuring a well-controlled coupling Of IC and CE separations. Proof-of-concept measurements were performed Using a model system consisting of nucleotides and cyclic nucleotides. The data are presented in a multidimensional contour plot. Analyte stacking in the CE separation could be exploited on the basis of the fact that the suppressed IC effluent is pure water.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHASE LIQUID-CHROMATOGRAPHY; FLOW GATING INTERFACE; ELECTROSPRAY-IONIZATION; ZONE-ELECTROPHORESIS; GAS-CHROMATOGRAPHY; BATCH INJECTION; MICROCOLUMN-LC; SYSTEM; ONLINE; SUPPRESSOR; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Instrumentelle Analytik (Prof. Frank-Michael Matysik) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jul 2019 14:07 |
| Last Modified: | 22 Jul 2019 14:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5779 |
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