Pandamooz, Sareh and Jurek, Benjamin and Meinung, Carl-Philipp and Baharvand, Zahra and Shahem-Abadi, Alireza Sahebi and Haerteis, Silke and Miyan, Jaleel A. and Downing, James and Dianatpour, Mehdi and Borhani-Haghighi, Afshin and Salehi, Mohammad Saied (2022) Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 62. pp. 25-53. ISSN 0362-1642, 1545-4304
Full text not available from this repository. (Request a copy)Abstract
In December 2019, a novel coronavirus crossed species barriers to infect humans and was effectively transmitted from person to person, leading to a worldwide pandemic. Development of effective clinical interventions, including vaccines and antiviral drugs that could prevent or limit the burden or transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health priority. It is thus of utmost importance to assess possible therapeutic strategies against SARS-CoV-2 using experimental models that recapitulate aspects of the human disease. Here, we review available models currently being developed and used to study SARS-CoV-2 infection and highlight their application to screen potential therapeutic approaches, including repurposed antiviral drugs and vaccines. Each identified model provides a valuable insight into SARS-CoV-2 cellular tropism, replication kinetics, and cell damage that could ultimately enhance understanding of SARS-CoV-2 pathogenesis and protective immunity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | in vitro models; animal models |
| Subjects: | 500 Science > 570 Life sciences 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Molecular and Cellular Neurobiology (Prof. Dr. Peter J. Flor) Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 Jul 2024 09:54 |
| Last Modified: | 16 Jul 2024 09:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57852 |
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