Kurt, Birguel and Kurtz, Armin (2015) Plasticity of renal endocrine function. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 308 (6). R455-R466. ISSN 0363-6119, 1522-1490
Full text not available from this repository. (Request a copy)Abstract
The kidneys are important endocrine organs. They secrete humoral factors, such as calcitriol, erythropoietin, klotho, and renin into the circulation, and therefore, they are essentially involved in the regulation of a variety of processes ranging from bone formation to erythropoiesis. The endocrine functions are established by cells, such as proximal or distal tubular cells, renocortical interstitial cells, or mural cells of afferent arterioles. These endocrine cells are either fixed in number, such as tubular cells, which individually and gradually upregulate or downregulate hormone production, or they belong to a pool of cells, which display a recruitment behavior, such as erythropoietin- and renin-producing cells. In the latter case, regulation of humoral function occurs via (de)recruitment of active endocrine cells. As a consequence renin- and erythropoietin-producing cells in the kidney show a high degree of plasticity by reversibly switching between distinct cell states. In this review, we will focus on the characteristics of renin-and of erythropoietin-producing cells, especially on their origin and localization, their reversible transformations, and the mediators, which are responsible for transformation. Finally, we will discuss a possible interconversion of renin and erythropoietin expression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ERYTHROPOIETIN GENE-EXPRESSION; RENIN-ANGIOTENSIN SYSTEM; HYPOXIA-INDUCIBLE FACTOR-1; SECRETED KLOTHO PROTEIN; SMOOTH-MUSCLE-CELLS; MESSENGER-RNA; JUXTAGLOMERULAR APPARATUS; VITAMIN-D; SODIUM APPETITE; TRANSGENIC MICE; calcitriol; erythropoietin; klotho; renin |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Petra Gürster |
| Date Deposited: | 20 Aug 2020 06:10 |
| Last Modified: | 20 Aug 2020 06:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5786 |
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