Nolde, Michael and Holtfreter, Birte and Kocher, Thomas and Alayash, Zoheir and Reckelkamm, Stefan Lars and Ehmke, Benjamin and Baurecht, Hansjoerg and Baumeister, Sebastian-Edgar (2022) No bidirectional relationship between depression and periodontitis: A genetic correlation and Mendelian randomization study. FRONTIERS IN IMMUNOLOGY, 13: 918404. ISSN 1664-3224,
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BackgroundObservational and in-vivo research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation. MethodsThe study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,563 to 797,563 individuals of European ancestry. We performed linkage disequilibrium score regression (LDSC) to estimate global correlation and used Heritability Estimation from Summary Statistics (rho-HESS) to further examine local genetic correlation. Latent Heritable Confounder Mendelian randomization (LHC-MR), Causal Analysis using Summary Effect estimates (CAUSE), and conventional MR approaches assessed bidirectional causation. ResultsLDSC observed only weak genetic correlation (r(g) = 0.06, P-Value = 0.619) between depression and periodontitis. Analysis of local genetic correlation using rho-HESS did not reveal loci of significant local genetic covariance. LHC-MR, CAUSE and conventional MR models provided no support for bidirectional causation between depression and periodontitis, with odds ratios ranging from 1.00 to 1.06 in either direction. ConclusionsResults do not support shared heritability or a causal connection between depression and periodontitis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMPLANT DISEASES; CONSENSUS REPORT; ASSOCIATION; WORKSHOP; periodontitis; mendelian randomization analysis; depression; genetic correlation; genetic correlation analysis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Feb 2024 08:09 |
| Last Modified: | 27 Feb 2024 08:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57882 |
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