Saitou, Moe and Noda, Kentaro and Matsushita, Takayuki and Ukichi, Taro and Kurosaka, Daitaro (2022) Central sensitisation features are associated with neuropathic pain-like symptoms in patients with longstanding rheumatoid arthritis: a cross-sectional study using the central sensitisation inventory. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 40 (5). pp. 980-987. ISSN 0392-856X, 1593-098X
Full text not available from this repository. (Request a copy)Abstract
Objective Several studies have indicated that arthralgia may be driven by central sensitisation. Central sensitivity syndrome (CSS) is a concept that unifies various symptoms due to central sensitisation. Recently, the central sensitisation inventory (CSI) was developed as a screening questionnaire to detect CSS. Using the CSI, we examined the prevalence, the clinical characteristics of CSS, and the association between CSS and neuropathic pain (NP)-like symptoms among rheumatoid arthritis (RA) patients. Methods The CSI was administered to 240 RA outpatients. We evaluated their disease activity and several potentially relevant patient-reported outcomes. We compared the clinical parameters depending on the severity of CSS and examined the effect of the CSI score on NP-like symptoms among the relevant clinical parameters using multivariate analyses. Results The mean disease duration was 9.58 +/- 7.76 years. Eighteen (7.5 %) patients had CSS, which was associated with evaluator global assessment (EGA) (odds ratio (OR) 0.860); fibromyalgia symptom scale (OR 1.46); painDETECT questionnaire score (OR 1.24); hospital anxiety and depression scale-anxiety (OR 1.35); and physical (OR 0.898), mental (OR 0.828), and role-social (OR 0.946) component summary scores on the Short-Form 36-Item Health Survey. CSI score was the factor that contributed most to NP-like symptoms (p=0.000, beta=0.266). Conclusion NP-like symptoms might be one of the symptoms of CSS in longstanding RA patients. In longstanding RA patients who have disproportionately greater NP-like symptoms and/or widespread pain compared with degree of inflammation, detecting CSS using CSI might help to understand the pathogenesis of patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PRELIMINARY DIAGNOSTIC-CRITERIA; AMERICAN-COLLEGE; DISEASE-ACTIVITY; FIBROMYALGIA; MECHANISMS; CLASSIFICATION; ADAPTATION; VALIDATION; VERSION; rheumatoid arthritis; central sensitisation; neuropathic pain; fibromyalgia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Feb 2024 10:20 |
| Last Modified: | 27 Feb 2024 10:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57890 |
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