Meuth, Sven G. and Bayas, Antonios and Kallmann, Boris and Linker, Ralf and Rieckmann, Peter and Wattjes, Mike P. and Maeurer, Mathias and Kleinschnitz, Christoph (2022) Long-term management of multiple sclerosis patients treated with cladribine tablets beyond year 4. EXPERT OPINION ON PHARMACOTHERAPY, 23 (13). pp. 1503-1510. ISSN 1465-6566, 1744-7666
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Introduction Oral cladribine is a highly effective pulsed selective immune reconstitution therapy licensed for relapsing multiple sclerosis (RMS) since 2017. A full treatment course comprises two treatment cycles given 1 year apart, followed by two treatment-free years. The management of cladribine-treated patients beyond year 4 needs to be addressed as patients have now passed the initial 4 years since European Medical Agency approval. Areas covered A panel of neurologists and a neuroradiologist experienced in MS treatment/monitoring evaluated clinical trial data and real-world evidence and proposed recommendations for the management of cladribine-treated patients beyond year 4. Expert opinion Continuous monitoring of disease activity during the treatment-free period is important. Subsequent management depends on the presence or absence of inflammatory disease activity, determined in the absence of consistent guidelines via practice-driven neurological decision criteria. Persisting or newly occurring inflammatory disease activity is an indication for further treatment, i.e. either re-initiation of cladribine or switching to another highly effective disease-modifying therapy. The decision to retreat or switch should be based on clinical and radiological evaluation considering disease course, treatment history, and safety aspects. In the absence of disease activity, either retreatment can be offered, or the treatment-free period can be extended under structured monitoring.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TREATMENT PATTERNS; CELLS; Cladribine; disease activity; lymphocytes; monitoring; multiple sclerosis; pulsed selective immune reconstitution therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Feb 2024 10:17 |
| Last Modified: | 27 Feb 2024 10:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57928 |
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