Hampe, Tristan and Liersch, Julia and Wiechens, Bernhard and Wassmann, Torsten and Schubert, Andrea and Alhussein, Mohammad and Buergers, Ralf and Krohn, Sebastian (2022) A Pilot Study on Monomer and Bisphenol A (BPA) Release from UDMA-Based and Conventional Indirect Veneering Composites. POLYMERS, 14 (21): 4580. ISSN , 2073-4360
Full text not available from this repository. (Request a copy)Abstract
This study aimed to investigate the release of common monomers from conventional (Dialog Vario, Enamel Plus HFO) and UDMA-based indirect veneering composites (VITA VM LC, GC Gradia). Ten cylindrical samples of each material were prepared (n = 40), immersed in HPLC grade water, and incubated for 24 h in an incubation shaker at 37 degrees C and 112 rpm. Extraction was performed following ISO 10993-12 and monomers were detected and quantified by HPLC-MS/MS. In all the samples, urethane dimethacrylate (UDMA) and bisphenol A (BPA) were quantifiable. Compared to water blanks, BPA levels were only elevated in the eluates from conventional composites. In all other samples, concentrations were in the range of extraneous BPA and were therefore clinically irrelevant. Low concentrations of Bisphenol A-glycidyl methacrylate (BisGMA) were found in one BPA-free composite and in both conventional materials. Statistical analyses showed that BPA-free materials released significantly less BisGMA and no BPA, while UDMA elution was comparable to elution from conventional materials. All measured concentrations were below reported effective cytotoxic concentrations. Considering these results, the substitution of BPA-derivatives with UDMA might be beneficial since BPA-associated adverse effects are ruled out. Further studies should be enrolled to test the biocompatibility of UDMA on cells of the oral environment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DENTAL RESIN COMPOSITES; LEACHABLE COMPONENTS; BIS-GMA; HPLC ANALYSIS; IN-VITRO; GINGIVAL FIBROBLASTS; OXIDATIVE STRESS; HUMAN EXPOSURE; INDOOR DUST; BULK-FILL; materials testing; dental materials; indirect composite; urethane dimethacrylate; bisphenol A; bisphenol A-glycidyl methacrylate |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Feb 2024 11:24 |
| Last Modified: | 27 Feb 2024 11:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57943 |
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