Quach, Stefanie and Holzgreve, Adrien and Kaiser, Lena and Unterrainer, Marcus and Dekorsy, Franziska J. and Nelwan, Debie and Bartos, Laura M. and Kirchleitner, Sabrina and Weller, Jonathan and Weidner, Lorraine and Niyazi, Maximilian and Ruf, Viktoria C. and Herms, Jochen and Stoecklein, Sophia and Wetzel, Christian and Riemenschneider, Markus J. and Baumgarten, Louisa and Thon, Niklas and Brendel, Matthias and Rupprecht, Rainer and Bartenstein, Peter and Tonn, Joerg-Christian and Albert, Nathalie L. (2023) TSPO PET signal using [F-18]GE180 is associated with survival in recurrent gliomas. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 50 (3). pp. 859-869. ISSN 1619-7070, 1619-7089
Full text not available from this repository. (Request a copy)Abstract
Purpose Glioma patients, especially recurrent glioma, suffer from a poor prognosis. While advances to classify glioma on a molecular level improved prognostication at initial diagnosis, markers to prognosticate survival in the recurrent situation are still needed. As 18 kDa translocator protein (TSPO) was previously reported to be associated with aggressive histopathological glioma features, we correlated the TSPO positron emission tomography (PET) signal using [F-18]GE180 in a large cohort of recurrent glioma patients with their clinical outcome. Methods In patients with [F-18]GE180 PET at glioma recurrence, [F-18]GE180 PET parameters (e.g., SUVmax) as well as other imaging features (e.g., MRI volume, [F-18]FET PET parameters when available) were evaluated together with patient characteristics (age, sex, Karnofsky-Performance score) and neuropathological features (e.g. WHO 2021 grade, IDH-mutation status). Uni- and multivariate Cox regression and Kaplan-Meier survival analyses were performed to identify prognostic factors for post-recurrence survival (PRS) and time to treatment failure (TTF). Results Eighty-eight consecutive patients were evaluated. TSPO tracer uptake correlated with tumor grade at recurrence (p < 0.05), with no significant differences in IDH-wild-type versus IDH-mutant tumors. Within the subgroup of IDH-mutant glioma (n = 46), patients with low SUVmax (median split, <= 1.60) had a significantly longer PRS (median 41.6 vs. 25.3 months, p = 0.031) and TTF (32.2 vs 8.7 months, p = 0.001). Also among IDH-wild-type glioblastoma (n = 42), patients with low SUVmax (<= 1.89) had a significantly longer PRS (median not reached vs 8.2 months, p = 0.002). SUVmax remained an independent prognostic factor for PRS in the multivariate analysis including CNS WHO 2021 grade, IDH status, and age. Tumor volume defined by [F-18]FET PET or contrast-enhanced MRI correlated weakly with TSPO tracer uptake. Treatment regimen did not differ among the median split subgroups. Conclusion Our data suggest that TSPO PET using [F-18]GE180 can help to prognosticate recurrent glioma patients even among homogeneous molecular subgroups and may therefore serve as valuable non-invasive biomarker for individualized patient management.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CENTRAL-NERVOUS-SYSTEM; TRANSLOCATOR PROTEIN; BENZODIAZEPINE-RECEPTOR; RESPONSE ASSESSMENT; HUMAN ASTROCYTOMAS; F-18-FET PET; BRAIN; TRACER; TUMORS; GRADE; TSPO; [F-18]GE180 PET; Glioma; Survival; Prognostic biomarker |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Neuropathologie Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Mar 2024 14:53 |
| Last Modified: | 05 Mar 2024 14:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57962 |
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