Zhao, Gang and Straub, Rainer H. and Meyer-Hermann, Michael (2022) The transition between acute and chronic infections in light of energy control: a mathematical model of energy flow in response to infection. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 19 (191): 20220206. ISSN 1742-5689, 1742-5662
Full text not available from this repository. (Request a copy)Abstract
Background: Different parts of an organism like the gut, endocrine, nervous and immune systems constantly exchange information. Understanding the pathogenesis of various systemic chronic diseases increasingly relies on understanding how these subsystems orchestrate their activities. Methods: We started from the working hypothesis that energy is a fundamental quantity that governs activity levels of all subsystems and that interactions between subsystems control the distribution of energy according to acute needs. Based on physiological knowledge, we constructed a mathematical model for the energy flow between subsystems and analysed the resulting organismal responses to in silico infections. Results: The model reproduces common behaviour in acute infections and suggests several host parameters that modulate infection duration and therapeutic responsiveness. Moreover, the model allows the formulation of conditions for the induction of chronic infections and predicts that alterations in energy released from fat can lead to the transition from clearance of acute infections to a chronic inflammatory state. Impact: These results suggest a fundamental role for brain and fat in controlling immune response through systemic energy control. In particular, it suggests that lipolysis resistance, which is known to be involved in obesity and ageing, might be a survival programme for coping with chronic infections.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; CHRONIC INFLAMMATION; IMMUNE; OBESITY; ACTIVATION; RESISTANCE; LIPOLYSIS; DISEASE; STRESS; LINK; energy; inter-organ interactions; infections; immune response; lipolysis resistance; ageing |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Feb 2024 10:48 |
| Last Modified: | 27 Feb 2024 10:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57963 |
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