Hellstern, V and Perez, M. Aguilar and Henkes, E. and Donauer, E. and Wendl, C. and Baezner, H. and Ganslandt, O. and Henkes, H. (2022) Use of a p64 MW Flow Diverter with Hydrophilic Polymer Coating (HPC) and Prasugrel Single Antiplatelet Therapy for the Treatment of Unruptured Anterior Circulation Aneurysms: Safety Data and Short-term Occlusion Rates. CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 45 (9). pp. 1364-1374. ISSN 0174-1551, 1432-086X
Full text not available from this repository. (Request a copy)Abstract
Purpose To assess the safety and short-term occlusion rates in procedures using the p64 MW hydrophilic polymer-coated (HPC) flow diverter (FD) with prasugrel single antiplatelet therapy (SAPT) for the treatment of anterior circulation saccular aneurysms. Methods We retrospectively identified patients who underwent treatment of one or more intracranial anterior circulation saccular aneurysms between March 2020 and December 2021 with a p64 MW HPC FD and prasugrel SAPT with verified P2Y12 platelet receptor inhibition. Patients diagnosed with fusiform, dissecting, or recently ruptured aneurysms were excluded. Periprocedural and postprocedural complications, clinical outcomes, and angiographic follow-up results were evaluated. Results One hundred and two patients with 132 intracranial aneurysms met the inclusion criteria. Previous or concomitant treatments (e.g., coil occlusion) had been performed on 18 of these aneurysms. The technical success rate (i.e., implantation of the intended FD) was 100% with an average of 1.1 devices implanted per patient. Periprocedural and postprocedural complications occurred in 13.6% and 6.8% of these patients, respectively. No mortality or permanent clinical deterioration (i.e., modified Rankin scale score >= 3) were reported. Early follow-up digital subtraction angiography revealed aneurysmal occlusion rates of 72.6% and 83.8% at four and nine months, respectively. Conclusions The implantation of a p64 MW HPC FD with prasugrel SAPT is safe and results in rapid, reliable and effective aneurysmal occlusion.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PIPELINE EMBOLIZATION DEVICE; INTRACRANIAL ANEURYSMS; ENDOVASCULAR TREATMENT; SHIELD TECHNOLOGY; DIVERSION; MONOTHERAPY; OUTCOMES; FLEX; Aneurysm; Flow diverter; Anti-thrombogenic coating; Prasugrel; Single antiplatelet therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentrum für Neuroradiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Feb 2024 13:24 |
| Last Modified: | 08 Feb 2024 13:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57996 |
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