Graf, Marion and Böttcher, Hans-Christian and Czerwieniec, Rafal and Mayer, Peter and Thavalingam, Sugina and Metzler-Nolte, Nils (2022) Photophysical and structural characterization of the bis-cyclometalated compound [Ir(ptpy)(2)(?N-2-tppz)]PF(6 )and evaluation of its cytotoxic activity. INORGANICA CHIMICA ACTA, 534: 120806. ISSN 0020-1693, 1873-3255
Full text not available from this repository. (Request a copy)Abstract
The synthesis and structural characterization of the bis-cyclometalated compound [Ir(ptpy)(2)(kappa N-2-tppz)]PF6 2 (ptpy = 2-(p-tolyl)pyridinato, tppz = 2,3,5,6-tetrakis(2-pyridyl)pyrazine) is described. Compound 2 was pre-pared by reaction of [{Ir(mu-Cl)(ptpy)}(2)] (1) with tppz in a refluxing solution of CH2Cl2/MeOH and H2O. The resulting complex 2 was purified by chromatography and crystallized from dichloromethane/methanol/iso-hexane and its molecular structure confirmed by a single-crystal X-ray diffraction study. The emission spectrum of 2 exhibited the new compound as red-emitting phosphorescent complex. The cytotoxic potential of 2 was characterized by determination of the substance's IC50 value against two different human cancer cell lines (HT-29, MCF-7). In comparison to cisplatin, these values (1.4 mu M, 4.2 mu M) show a significant increase in cytotoxicity. spectra were recorded using a MAT 95 MS spectrometer. Elemental analyses (C, H, N) were performed by the Microanalytical Laboratory of the Department of Chemistry, LMU Munich, using a Heraeus Elementar Vario EL instrument.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IRIDIUM COMPLEXES; CISPLATIN; LIGANDS; Crystal structure; Cyclometalated complexes; Cytotoxic activity; Iridium; Luminescence properties |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry III - Physical Chemistry (Molecular Spectroscopy and Photochemistry) > Prof. Dr. Hartmut Yersin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jan 2024 13:39 |
| Last Modified: | 26 Jan 2024 13:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58028 |
Actions (login required)
 |
View Item |
