Jantsch, Jonathan and Schatz, Valentin and Friedrich, Diana and Schroeder, Agnes and Kopp, Christoph and Siegert, Isabel and Maronna, Andreas and Wendelborn, David and Linz, Peter and Binger, Katrina J. and Gebhardt, Matthias and Heinig, Matthias and Neubert, Patrick and Fischer, Fabian and Teufel, Stefan and David, Jean-Pierre and Neufert, Clemens and Cavallaro, Alexander and Rakova, Natalia and Kueper, Christoph and Beck, Franz-Xaver and Neuhofer, Wolfgang and Muller, Dominik N. and Schuler, Gerold and Uder, Michael and Bogdan, Christian and Luft, Friedrich C. and Titze, Jens (2015) Cutaneous Na+ Storage Strengthens the Antimicrobial Barrier Function of the Skin and Boosts Macrophage-Driven Host Defense. CELL METABOLISM, 21 (3). pp. 493-501. ISSN 1550-4131, 1932-7420
Full text not available from this repository. (Request a copy)Abstract
Immune cells regulate a hypertonic microenvironment in the skin; however, the biological advantage of increased skin Na+ concentrations is unknown. We found that Na+ accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania major as a model of skin-prone macrophage infection to test the hypothesis that skin-Na+ storage facilitates antimicrobial host defense. Activation of macrophages in the presence of high NaCl concentrations modified epigenetic markers and enhanced p38 mitogen-activated protein kinase (p38/MAPK)dependent nuclear factor of activated T cells 5 (NFAT5) activation. This high-salt response resulted in elevated type-2 nitric oxide synthase (Nos2)-dependent NO production and improved Leishmania major control. Finally, we found that increasing Na+ content in the skin by a high-salt diet boosted activation of macrophages in a Nfat5-dependent manner and promoted cutaneous antimicrobial defense. We suggest that the hypertonic microenvironment could serve as a barrier to infection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENHANCER-BINDING PROTEIN; EPIDERMAL BARRIER; NITRIC-OXIDE; IN-VIVO; SODIUM; TRANSCRIPTION; RECEPTORS; INDUCTION; STRESS; TISSUE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Jul 2019 10:39 |
| Last Modified: | 24 Jul 2019 10:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5808 |
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