Ortmann, O. and Blohmer, J-U and Sibert, N. T. and Brucker, S. and Janni, W. and Wockel, A. and Scharl, A. and Dieng, S. and Ferencz, J. and Inwald, E. C. and Wesselmann, S. and Kowalski, C. (2023) Current clinical practice and outcome of neoadjuvant chemotherapy for early breast cancer: analysis of individual data from 94,638 patients treated in 55 breast cancer centers. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 149 (3). pp. 1195-1209. ISSN 0171-5216, 1432-1335
Full text not available from this repository. (Request a copy)Abstract
Neoadjuvant chemotherapy (NACT) is frequently used in patients with early breast cancer. Randomized controlled trials have demonstrated similar survival after NACT or adjuvant chemotherapy (ACT). However, certain subtypes may benefit more when NACT contains regimes leading to high rates of pathologic complete response (pCR) rates. In this study we analyzed data using the OncoBox research from 94,638 patients treated in 55 breast cancer centers to describe the current clinical practice of and outcomes after NACT under routine conditions. These data were compared to patients treated with ACT. 40% of all patients received chemotherapy. The use of NACT increased over time from 5% in 2007 up to 17.3% in 2016. The proportion of patients receiving NACT varied by subtype. It was low in patients with HR-positive/HER2-negative breast cancer (5.8%). However, 31.8% of patients with triple-negative, 31.9% with HR-negative/HER2-positive, and 26.5% with HR-positive/HER2-positive breast cancer received NACT. The rates of pCR were higher in patients with HR-positive/HER2-positive, HR-negative/HER2-positive and triple-negative tumors (36, 53 and 38%) compared to HR-positive/HER2-negative tumors (12%). PCR was achieved more often in HER2-positive and triple-negative tumors over time. This is the largest study on use and effects of NACT in German breast cancer centers. It demonstrates the increased use of NACT based on recommendations in current clinical guidelines. An improvement of pCR was shown in particular in HER2-positive and triple-negative breast cancer, which is consistent with data from randomized controlled trails.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PATHOLOGICAL COMPLETE RESPONSE; METAANALYSIS; Early breast cancer; Neoadjuvant chemotherapy; Breast cancer centers; Guidelines; Oncobox research |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Mar 2024 10:33 |
| Last Modified: | 07 Mar 2024 10:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58131 |
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