Grevenstein, David and Schafigh, Darius and Oikonomidis, Stavros and Eysel, Peer and Brochhausen, Christoph and Spies, Christian Karl and Oppermann, Johannes (2022) Short-term radiological results after spheroid-based autologous chondrocyte implantation in the knee are independent of defect localisation. TECHNOLOGY AND HEALTH CARE, 30 (3). pp. 725-733. ISSN 0928-7329, 1878-7401
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BACKGROUND: Lesions of articular cartilage represent a crucial risk factor for the early development of osteoarthritis. Autologous chondrocyte implantation (ACI) is a well-established procedure in therapy of those lesions in the knee. The aim of the presented study is to detect differences in short-term radiological outcome depending on defect localization (femoral condyle vs. retropatellar) after spheroid-based ACI. OBJECTIVE: This study aimed to demonstrate that radiological outcome after spheroid-based ACI in the knee is independent of defect localization. METHODS: MRI-scans after retropatellar ACI and ACI of the medial/lateral femoral condyle, with a preoperative Outerbridge grade of III or IV were evaluated regarding MOCART 2.0. RESULTS: The mean defect-size was 5.0 +/- 1.8 cm(2), with a minimum size of 2 cm(2) and a maximum size of 9 cm(2). Scans were performed 7.7 months (+/- 3.1 months) postoperatively. The mean MOCART 2.0 score was 78.5 +/- 15.6. No statistically significant influence neither of the localization (p = 0.159), the gender (p = 0.124) nor defect size (< 5 cm(2) vs. > 5 cm(2); p = 0.201) could be observed. CONCLUSIONS: The presented data demonstrate good to excellent radiological short-term results after spheroid-based ACI. Data indicates, that at least radiological results are independent of gender, defect-size and defect-localization.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARTILAGE REPAIR TISSUE; OSTEOCHONDRAL DEFECTS; FOLLOW-UP; PERIOSTEUM; OUTCOMES; Knee; cartilage; autologous chondrocyte implantation; spheroids; osteoarthritis; ACI |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Feb 2024 16:17 |
| Last Modified: | 27 Feb 2024 16:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58138 |
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